Tazobactam acid

Research use only, not for human use.

Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.(In Vitro):Tazobactam (CL-298741) (5 μg/mL; 18 hours) has bactericidal activity and inhibit the growth of the bacteria in a dose-dependent manner.Tazobactam (CL-298741) (1-10 μg/mL; 6 hours; Prot. vulgaris and M. morgan) inhibits various types β-lactamase activity and with ID50 values of ＜ 10 μg/mL, respectively.(In Vivo):Tazobactam (CL-298741) (1000 mg/kg; i.p.; four times a day, for 36 and 84 hours; BALB/c mice) decreases the number of bacteria in mice and survived in low doses.

Tazobactam (CL-298741) (5 μg/mL; 18 hours) has bactericidal activity and inhibit the growth of the bacteria in a dose-dependent manner.Tazobactam (CL-298741) (1-10 μg/mL; 6 hours; Prot. vulgaris and M. morgan) inhibitsvarious types β-lactamase activity and with ID50 values of ＜ 10 μg/mL, respectively.

Tazobactam (CL-298741) (1000 mg/kg; i.p.; four times a day, for 36 and 84 hours; BALB/c mice) decreases the number of bacteria in mice and survived in low doses. Animal Model:BALB/c mice Dosage:1000 mg/kg Administration:Intraperitoneal injection; four times a day, for 36 and 84 hours Result:Decraesed the number of bacteria and neutrophils in BALF than in the control group.

CL-298741 | YTR 830H

Microbiology/Virology

Antibiotic

β-Lactamase

Infection

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89786-04-9

300.29

C10H12N4O5S

>98% (HPLC)

DMSO: 10 mM

C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3

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(-20℃)

With Ice Pack

≥ 2 years